Semaglutide is a powerful tool for weight loss, but like any medication it can bring side effects. One you might notice early on is constipation. Below, you’ll find why it happens, how long it tends to last, and practical ways to feel better—without derailing your progress.
Why Semaglutide Can Slow Things Down
Semaglutide helps control appetite and slows how quickly food moves through the stomach and intestines. That slower “transit time” can:
- Reduce the number of bowel movements
- Let the colon pull more water from stool
- Make stools drier and harder to pass
Lower food volume (because you’re less hungry) and not drinking quite as much can compound the issue. The same mechanism that supports weight loss can temporarily challenge your gut.
How Long Does It Usually Last?
For many people, constipation improves as the body adapts—often over several weeks. Some will breeze through with minimal changes; others may need a few targeted tweaks. If symptoms linger or worsen, it’s worth checking in with your clinician for tailored guidance.
Relief Roadmap: What Actually Helps
- Hydrate on purpose
Aim for ~8 cups (about 2 liters) of fluids daily unless your clinician advises otherwise. Water, herbal tea, and broths count. If you sweat a lot, add electrolytes. - Build fiber gradually
Target 25–35 grams per day from foods such as oats, whole grains, beans, lentils, leafy greens, berries, chia, and flax. Increase slowly over a week and pair fiber with fluids to avoid bloating. If food alone isn’t enough, ask your provider about a gentle fiber supplement. - Move your body (especially after meals)
Post-meal walks and regular activity stimulate the gut. Even 10–15 minutes after breakfast or dinner can help; aim for at least 60 minutes of moderate movement weekly. - Create a bathroom routine (and use a footstool)
Try going at a consistent time—often after meals. A small footstool can straighten the anorectal angle and make passing stool easier. Take your time and avoid straining. - Short-term over-the-counter options
If lifestyle steps aren’t enough, a clinician or pharmacist may suggest a stool softener or a gentle osmotic laxative for brief use. These can be helpful as you adjust, but they’re not meant as long-term crutches. - Titrate thoughtfully
If constipation persists, talk with your prescriber about slowing dose increases or adjusting timing. A small change in your schedule can improve tolerance. - When to call your clinician
Seek medical advice if you have severe or worsening abdominal pain, vomiting, blood in stool, black stools, fever, or if you can’t pass stool or gas.
Other GI Effects You Might Notice
Some people also report nausea, diarrhea, abdominal discomfort, or occasional vomiting—most are temporary and improve as your body acclimates.
Bottom Line
Constipation with semaglutide is common—and manageable. Hydration, gradual fiber, regular movement, a consistent bathroom routine, and short-term OTC support (when appropriate) usually do the trick. Partner with your provider if symptoms persist so you can stay on track with your weight-loss plan.
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